Innovative blood-based liver biomarkers – hepatomiR®
The hepatomiR® test satisfies the urgent clinical need for an easily assessable preoperative test to predict liver function recovery after partial liver resection. This is critical to identify patients with high risk of postoperative liver dysfunction, and to plan according risk reduction measures.
The hepatomiR® test enables quantitative analysis of three liver-enriched microRNAs hsa-miR-122-5p, hsa-miR- 192-5p, and hsa-miR-151a-5p in plasma samples. Our proprietary algorithm converts miRNA levels into a risk score that predicts postoperative liver dysfunction: Starlinger et al., HEPATOLOGY, Vol. 69, No. 6, 2019
Based on validated cut-off values for patient stratification, we have confirmed excellent prognostic performance in a cohort of HCC, CCC, and mCRC patients:
- Positive predictive value (PPV): 83%
- Negative predictive value (NPV): 85%
- Odd’s Ratio: 19.7