The world of non-coding RNAs is continually expanding, revealing new layers of biological complexity and therapeutic potential. Among the most exciting discoveries are circular RNAs (circRNAs). Unlike their linear counterparts, circRNAs form covalently closed loops, granting them remarkable stability and unique functions in gene regulation. This intrinsic stability, coupled with their presence in biofluids, positions circRNAs as powerful new candidates for biomarker discovery and novel therapeutic targets.

The Challenge of CircRNA Analysis from Biofluids

Despite their immense promise, accurately isolating and quantifying circRNAs, especially from challenging biofluid samples like plasma and serum, has presented significant technical hurdles. These samples typically contain very low concentrations of circRNAs alongside a vast excess of highly abundant linear RNAs (like ribosomal RNA and messenger RNA fragments). This contamination often leads to:

  • Low circRNA yield.
  • Compromised detection sensitivity.
  • Difficulty in distinguishing true circRNAs from linear RNA artifacts.

These challenges have historically limited the widespread application of circRNAs in clinical and translational research.

TAmiRNA’s Solution: An Optimized Workflow for Robust circRNA Analysis

At TAmiRNA, we are committed to pushing the boundaries of RNA biomarker discovery. We are thrilled to announce the launch of our new circRNA Analysis Service, built upon a meticulously optimized workflow for circRNA isolation and detection from biofluids.

Our dedicated team has developed and validated a proprietary process, ensuring high purity, enhanced yield, and superior detection sensitivity. This cutting-edge workflow minimizes linear RNA contamination and maximizes the capture of genuine circRNAs, even from low-input, complex biological samples.

Want to dive into the technical details? We’ve summarized our established workflow in our latest TechNote: Download our TechNote: Optimized circRNA Isolation & Detection from Biofluids Here

Key Advantages for Your Research:

Our new circRNA analysis service offers distinct benefits for researchers aiming to harness the potential of circRNAs:

  • Enhanced Sensitivity: Detect low-abundance circRNAs in complex biofluids.
  • High Purity: Minimize linear RNA contamination for more accurate quantification.
  • Robust & Reproducible Data: Gain confidence in your findings with a validated workflow.
  • Comprehensive Bioinformatics: Go beyond simple detection with advanced quantification and differential expression analysis.
  • Applicability to Diverse Samples: Ideal for plasma, serum, urine, and other challenging biofluid samples.

Accelerate Your CircRNA Discoveries

Whether you’re exploring novel disease biomarkers, investigating fundamental gene regulatory mechanisms, or seeking new therapeutic targets, our optimized circRNA analysis service provides the high-quality data you need.

By partnering with TAmiRNA, you can leverage our decade-plus of expertise in non-coding RNA analysis, allowing you to focus on the biological interpretation of your results, rather than the technical complexities of sample preparation.

Ready to unlock the full potential of circRNAs in your research?

Contact our experts today to discuss your project and learn how our new circRNA Analysis Service can accelerate your discoveries.