microRNA biomarkers of toxicity
The term toxomiR® refers to a selection of 19 microRNAs that are enriched in various tissues. Toxicant-induced changes in the transcription and secretion of toxomiRs® are highly sensitive to toxic effects occuring in the liver, kidney, central nervous system, heart, muscle, lung, pancreas, vascular injury, and due to endocrine disruption. ToxomiRs® can be analyzed in serum or plasma.
This review recently published, gives detailed insight into the clinical utility of circulating microRNAs as biomarkers of toxicity.