miRNA Archives - Tamirna - stability for life

A New Milestone in EV-Based Therapies Research

2026-05-08T11:11:22+02:00May 8th, 2026|EV characterization, exosomes, extracellular vesicle, microRNA, microRNA services, microRNAs, Parkinson’s Disease|Comments Off on A New Milestone in EV-Based Therapies Research

A major hurdle in EV-based therapies is the "yield gap" — standard lab protocols simply cannot produce the volume of extracellular vesicles (EVs) required for clinical applications. However, scale-up could impact the quality and potency of therapeutic EVs. In our latest co-authored study published in 𝗦𝘁𝗲𝗺 𝗖𝗲𝗹𝗹𝘀 𝗧𝗿𝗮𝗻𝘀𝗹𝗮𝘁𝗶𝗼𝗻𝗮𝗹 𝗠𝗲𝗱𝗶𝗰𝗶𝗻𝗲, the teams at Exosomica, the Innovative Medicine Centre, the University of Latvia, alongside TAmiRNA scientists, addressed this challenge head-on. Together, we applied deep molecular fingerprinting and in vivo potency studies to validate a new large-scale production protocol for Parkinson’s Disease (PD) therapies. By leveraging our specialized transcriptomic and proteomic pipelines, we analyzed how production and purification methods shape the EV "message": ✅ 𝟯𝗗 𝘃𝘀. 𝟮𝗗 𝗖𝗼𝗺𝗽𝗮𝗿𝗶𝘀𝗼𝗻: Our analysis [...]

New publication in Biomaterials

Huge congrats to Cansu Gorgun and the teams at Royal College of Surgeons in Ireland (RCSI) and Trinity College Dublin on their new publication in Biomaterials! This study is a fascinating look at how we can "train" macrophages to do two things at once. By reprogramming their metabolism, the team produced hybrid M1/M2 extracellular vesicles — a "dual-action" package that combines pro-inflammatory and pro-healing signals. We were lucky enough to support this work at 𝗧𝗔𝗺𝗶𝗥𝗡𝗔 by characterizing the EV miRNA cargo and looking into the functional implications of these hybrid vesicles. It’s a clever, elegant approach that opens new possibilities for smarter wound healing, tissue repair, and cell-free regenerative therapies. Fantastic work by everyone involved! TAmiRNA EV [...]