Cell-type specific and space-resolved RNA profiling in complex tissues
Healthy and malignant tissues are composed of multiple cell types: tumor and stromal cells, microvasculature and other specialized cell types (e.g., Tumor Infiltrating Lymphocytes). Therefore, the analysis of whole tumors results in a mixture of signals with unclear origin. Deconvolution of tissue heterogeneity and sensitive analytical methods are essential to obtain interpretable results from tissue analysis.
TAmiRNA and Dutch company Vivomicx have combined their respective technologies of high sensitivity gene expression profiling (RT-qPCR and smallRNAseq/RNAseq) and laser microdissection to enable cell-type specific and space-resolved RNA expression analysis in complex tissues.
This technology provides more accurate information on cellular states during onset and progression of diseases to accelerate drug and biomarker discovery.